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March 20, 2018

PDRN Healer: A Novel Therapeutic Option for Pigmentation

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What is PDRN Healer?

There has been a lot of talk about PDRN Healer or rather 婴儿针. Most clinics promote it as a general anti-ageing agent and collagen stimulator for acne scar treatment. However, a lesser know and often overlooked application for PDRN Healer is in the control of pigmentation problems like Melasma and PIH (Post-Inflammatory Pigmentation).

In short, PDRN Healer is a product that consists of DNA material called PN Polynucleotide extracted from Salmon eggs. The fascinating properties of PDRN Healer include the promotion of healing, reduction in inflammation, stimulation of collagen production and reduction in pigment production amongst others. [1]

There has been a lot of talk about PDRN Healer or rather 婴儿针. Most clinics promote it as a general anti-ageing agent and collagen stimulator for acne scar treatment. However, a lesser know and often overlooked application for PDRN Healer is in the control of pigmentation problems like Melasma and PIH (Post-Inflammatory Pigmentation).

How does PDRN Healer alleviate Pigmentation?

PDRN Healer has been shown in clinical studies to reduce pigment production right at the cellular level. In a clinical study conducted by Dr S E Chang et al in the International Journal of Molecular Sciences, proteins related to genes involved in pigment production were down-regulated.

This study opened up an entirely new area of therapeutic function for PDRN Healer in addition to anti-ageing and collagen production. We now have at our disposal, an option to combat Pigmentation and Melasma at the cellular level.

Can PDRN Healer be combined with Lasers and Plasma treatment?

My patients currently on Pico Laser or BB Laser are being stepped up to a combination treatment with PDRN Healer and have seen good results. Not only does it help with their pigmentation, but it also provides for a clearer, smoother complexion. Pore and acne scars also improve at the same time. Some patients note a ‘Dewy Shine’.


What to expect during a PDRN Healer treatment session.

It’s actually a simple 4 step procedure with little downtime.

STEP 1 - Clean and Disinfect the Skin

STEP 2 - Apply topical numb cream

STEP 3 - Introduce the PDRN Healer evenly throughout

STEP 4 - Apply Antibiotic cream

I usually provide a calming, soap-free wash for the next 3-4 days. My patients go home with an antibiotic cream that they will apply after washing for the next few days. Some patients do return to work immediately after the procedure. We advise that they refrain from make-up for 24-48 hours.

  1. Pak, C. S., Lee, J., Lee, H., Jeong, J., Kim, E. H., Jeong, J., Choi, H., Kim, B., Oh, S., Kim, I., & Heo, C. Y. (2014). A phase III, randomized, double-blind, matched-pairs, active-controlled clinical trial and preclinical animal study to compare the durability, efficacy and safety between polynucleotide filler and hyaluronic acid filler in the correction of crow's feet: a new concept of regenerative filler. Journal of Korean medical science29 Suppl 3(Suppl 3), S201–S209. https://doi.org/10.3346/jkms.2014.29.S3.S201 (Retraction published J Korean Med Sci. 2016 Feb;31(2):330)

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