Pigmentation disorders such as melasma and post-inflammatory hyperpigmentation (PIH) are common concerns among individuals seeking skin clarity and even tone. While topical agents and laser treatments remain the mainstay for many, emerging therapies like polynucleotide-based skin injectables have shown promise in complementing traditional approaches.

What is Polynucleotide-Based Therapy?

Polynucleotides (PN) are DNA fragments derived from natural sources such as salmon DNA. These molecules have been studied for their regenerative properties, including the ability to stimulate skin repair, support collagen synthesis, reduce inflammation, and assist in evening out pigmentation. In aesthetic medicine, these injectables are administered into the dermal layers to target a variety of skin concerns.

How It May Help with Pigmentation

Recent studies have explored how polynucleotide-based injectables can affect melanogenesis—the process responsible for pigment production in the skin. Findings suggest that this therapy may help reduce excess melanin formation by regulating proteins associated with pigmentation. When combined with a comprehensive pigmentation management plan, it may support clearer and more balanced skin tone.

While these results are promising, individual responses can vary. Suitability for such treatments should always be determined through consultation with a licensed medical practitioner.

Can It Be Combined with Other Treatments?

Polynucleotide injectables may be used alongside other modalities such as laser treatments or plasma therapy for synergistic benefits. When used in combination under medical guidance, patients may experience improvements not only in pigmentation but also in overall skin texture, pore appearance, and post-acne scarring.

What to Expect During a Session

A typical session involves several steps:

1. Skin cleansing and disinfection
2. Application of a topical anaesthetic
3. Precise administration of the polynucleotide solution into targeted areas
4. Post-treatment application of a soothing cream

There may be minor redness or swelling after the procedure, which usually resolves within a few days. Most individuals can resume daily activities shortly after, although it is advisable to avoid makeup and rigorous activities for 24–48 hours.

Supporting Care

Aftercare may include the use of gentle, soap-free cleansers and application of moisturisers or antibiotics as prescribed. Adherence to post-treatment advice helps minimise the risk of irritation and supports skin recovery.

In Summary

Polynucleotide-based skin injectables represent a novel and supportive approach to managing pigmentation concerns such as melasma and PIH. When used as part of a comprehensive, doctor-guided plan, they may help achieve smoother, brighter skin.

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Treatment suitability must be assessed by a licensed healthcare professional. Results may vary between individuals.

For more information on pigmentation management and available skin treatments, visit Cambridge Medical Group's pigmentation page.