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逆时针 Profhilo “Time Reversing Injection” - How does it work?

A “Time Reversing Injection” That Promises Natural, Yet Effective Results

For those looking into firming and improvement of skin elasticity but are not quite willing to venture into thread lifting or changing their facial profile with surgery, Profhilo may be the choice for you.

Known as the 逆时针 or “Time Reversing Injection”, Profhilo has been gaining popularity quickly as the choice of aesthetic treatment for those that have sagging skin. This bio-remodelling “injectable moisturiser” that addresses skin laxity and signs of ageing through the bio-stimulation of collagen, elastin and adipocytes (fats) that were lost through skin ageing.

Simply speaking, Profhilo not only helps with deep skin hydration, but it also adds just enough volume to even out fine lines and wrinkles, smoothing out skin texture. It will also help to boost collagen and elastin levels.

How does Profhilo work?

Profhilo is a skin treatment that is injected into all the layers of the skin, delivering hyaluronic acid (HA) in high concentrations and invokes a bio-remodelling process. The concentration of HA is 5 times more than the average skin booster treatment, at 64mg/2ml. This helps to stimulate the natural production of collagen and elastin in the skin. It is commonly referred to as an “injectable moisturiser”

Making use of thermal cross-linking NAHYCO technology, hyaluronic is released slowly over time, allowing for continuous yet natural-looking improvement. The change is subtle, yet effective and it will happen gradually over the course of a few weeks, making it the best choice for those that prefer a less detectable procedure.



  • High concentration of Hyaluronic Acid, both high-molecular & low-molecular
  • BDDE-free***
  • Non-crosslinked

2 sessions only, a month apart, yearly.

✓ Hydration
✓ Reduce fine lines
✓ Improve skin laxity
✓ Stimulate collagen & elastin
✓ Bio-remodel sagging skin
✓ Boost skin elastin levels


  • Normal HA

3 sessions, a month apart.
Every 6 months for maintenance.


(Such as Ellanse)

  • Poly-Caprolactone (PCL)

Every 2 years

✓ Restore volume
✓ Face augmentation (cheeks, chin, nose etc)

How does Profhilo work

Where and how is it administered?

Profhilo is mostly used to treat the lower face, and sometimes around the abdomen and neck & decolletage. Profhilo for the face is administered by the Bio Aesthetic Points (BAP) Technique, which includes only 5 injections on each side of the face, with 0.2ml in each point.

Other than the rejuvenating of the face, Profhilo may also be used for the abdominal and neck area. There are 10 BAP injection points for neck to anti-ageing benefits from the inside out, and 20 BAP injection points for the abdomen to provide efficient tightening.

How does Profhilo work
How does Profhilo work

Benefits of Profhilo

  • Dramatically hydrates skin
  • Provides firming, tightening, and lifting effect to the skin
  • Bio-stimulates elastin, 4 types of collagen and hydration in the 3 main layers of the skin
  • Smoothens fine lines and wrinkles
  • Boosts collagen and elastin
  • Less risk of lumpiness (As there is no BDDE)
  • Combination of both high-molecular and low-molecular HA
  • One of the highest concentrations of HA (64mg/2ml)
  • Provides tissue repair process, ideal for acne scarring


Is there downtime? What about pain?

There is no downtime needed for the treatment, although some may see slight bruising.

One should also avoid physical strain or sports for a day, and refrain from ingesting alcohol and anti-inflammatory medication for two days. It is a relatively quick procedure that can be done in ten minutes, during which you will experience slight discomfort. Topical numbing agents, as well as ice, can be applied for those that need it.


How often do I need to go for the procedure and when can I see results?

Profhilo is advised to be administered for at least 2 sessions, with 4 weeks apart between. Patients usually see results after 2 sessions.

Given that it is a bio-stimulator, results are delayed and can take between 3-6 months to show. The results last for about a year, with some repeating the treatments twice yearly.


Suggested treatment protocol

The treatment can be combined with other aesthetic therapies to help boost the stimulation of collagen to achieve the desired results such as FOTONA 4D® Laser, HIFU Doublo GOLD, AirJet Facelift etc.


Who is this treatment meant for?

This treatment is recommended for those above the age of 30, and someone lacking in skin laxity, looking for a subtle lift. For those that prefer a more dramatic result, a surgical or thread facelift may be advised.

In general, Profhilo is a quick and easy procedure that is relatively safe. Recommended for those that want firmer and more elastic skin, the injection delivers ample amounts of hydration with the use of hyaluronic acid, stimulating elastin and collagen naturally, without dramatically changing the facial line. It can be combined with other therapies to provide a more ideal result. Make sure to consult your doctor prior to any treatments or cosmetic procedures for a better gauge of if the treatment is suitable for you.


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