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30 minutes


Minimal discomfort with a slight sting during the injections. Topical numbing cream will be applied prior to the procedure.

  • Non-surgical
  • Medical-grade and effective
  • Improves skin tone, texture and laxity
  • Reduces sagging skin and fine lines
  • Increases skin hydration up to 20%
  • Encourages collagen production
  • Reduces skin laxity

You may experience lumps at the injection site, which will subside in 1 day

A “Time Reversing Injection” That Promises Natural, Yet Effective Results

For those looking into firming and improvement of skin elasticity but are not quite willing to venture into thread lifting or changing their facial profile with surgery, Profhilo may be the choice for you.

Known as the 逆时针 or “Time Reversing Injection”, Profhilo has been gaining popularity quickly as the choice of aesthetic treatment for those that have sagging skin. This bio-remodelling “injectable moisturiser” that addresses skin laxity and signs of ageing through the bio-stimulation of collagen, elastin and adipocytes (fats) that were lost through skin ageing.

Simply speaking, Profhilo not only helps with deep skin hydration, but it also adds just enough volume to even out fine lines and wrinkles, smoothing out skin texture. It will also help to boost collagen and elastin levels.

How does Profhilo work?

Profhilo is a skin treatment that is injected into all the layers of the skin, delivering hyaluronic acid (HA) in high concentrations and invokes a bio-remodelling process. The concentration of HA is 5 times more than the average skin booster treatment, at 64mg/2ml. This helps to stimulate the natural production of collagen and elastin in the skin. It is commonly referred to as an “injectable moisturiser”

Making use of thermal cross-linking NAHYCO technology, hyaluronic is released slowly over time, allowing for continuous yet natural-looking improvement. The change is subtle, yet effective and it will happen gradually over the course of a few weeks, making it the best choice for those that prefer a less detectable procedure.



  • High concentration of Hyaluronic Acid, both high-molecular & low-molecular
  • BDDE-free***
  • Non-crosslinked

2 sessions only, a month apart, yearly.

✓ Hydration
✓ Reduce fine lines
✓ Improve skin laxity
✓ Stimulate collagen & elastin
✓ Bio-remodel sagging skin
✓ Boost skin elastin levels


  • Normal HA

3 sessions, a month apart.
Every 6 months for maintenance.


(Such as Ellanse)

  • Poly-Caprolactone (PCL)

Every 2 years

✓ Restore volume
✓ Face augmentation (cheeks, chin, nose etc)

How does Profhilo work

Where and how is it administered?

Profhilo is mostly used to treat the lower face, and sometimes around the abdomen and neck & decolletage. Profhilo for the face is administered by the Bio Aesthetic Points (BAP) Technique, which includes only 5 injections on each side of the face, with 0.2ml in each point.

Other than the rejuvenating of the face, Profhilo may also be used for the abdominal and neck area. There are 10 BAP injection points for neck to anti-ageing benefits from the inside out, and 20 BAP injection points for the abdomen to provide efficient tightening.

How does Profhilo work
How does Profhilo work

Benefits of Profhilo

  • Dramatically hydrates skin
  • Provides firming, tightening, and lifting effect to the skin
  • Bio-stimulates elastin, 4 types of collagen and hydration in the 3 main layers of the skin
  • Smoothens fine lines and wrinkles
  • Boosts collagen and elastin
  • Less risk of lumpiness (As there is no BDDE)
  • Combination of both high-molecular and low-molecular HA
  • One of the highest concentrations of HA (64mg/2ml)
  • Provides tissue repair process, ideal for acne scarring


Is there downtime? What about pain?

There is no downtime needed for the treatment, although some may see slight bruising.

One should also avoid physical strain or sports for a day, and refrain from ingesting alcohol and anti-inflammatory medication for two days. It is a relatively quick procedure that can be done in ten minutes, during which you will experience slight discomfort. Topical numbing agents, as well as ice, can be applied for those that need it.


How often do I need to go for the procedure and when can I see results?

Profhilo is advised to be administered for at least 2 sessions, with 4 weeks apart between. Patients usually see results after 2 sessions.

Given that it is a bio-stimulator, results are delayed and can take between 3-6 months to show. The results last for about a year, with some repeating the treatments twice yearly.


suggested Profhilo treatment procedure

The treatment can be combined with other aesthetic therapies to help boost the stimulation of collagen to achieve the desired results such as FOTONA 4D® Laser, HIFU Doublo GOLD, AirJet Facelift etc.


Who is this treatment meant for?

This treatment is recommended for those above the age of 30, and someone lacking in skin laxity, looking for a subtle lift. For those that prefer a more dramatic result, a surgical or thread facelift may be advised.

In general, Profhilo is a quick and easy procedure that is relatively safe. Recommended for those that want firmer and more elastic skin, the injection delivers ample amounts of hydration with the use of hyaluronic acid, stimulating elastin and collagen naturally, without dramatically changing the facial line. It can be combined with other therapies to provide a more ideal result. Make sure to consult your doctor prior to any treatments or cosmetic procedures for a better gauge of if the treatment is suitable for you.

Authentic Profhilo

It is very important to make sure you're getting the right Profhilo, which are kept at proper temperatures to maintain its integrity and safety. Always stay safe and steer clear of fake Profhilo products to avoid health risks and complications. Find out more information regarding Profhilo at Cambridge Medical Group.

Profhilo Frequently Asked Questions

How much does Profhilo cost in Singapore?

The regulated price for Profhilo in Singapore is $1000 onwards per syringe, and this is dependent on how many sessions you require.

Does Profhilo really work?

Profhilo is a medical-grade, effective treatment that works for any skin type to improve skin tone, texture and elasticity. It works well in reducing signs of ageing, such as sagging skin and fine lines.

The treatment has been shown to result in a 20% increase in skin hydration, with a twelve-fold increase of collagen and elastin in the skin. Additionally, it lasts 8 times longer in the skin than regular non-cross-linked hyaluronic acid.

Can Profhilo go wrong? Is it dangerous?

A Profhilo treatment should be as safe as any hyaluronic acid filler when administered by a licensed doctor. Additionally, it is biocompatible as it is not mixed with other chemical agents and is made from hyaluronic acid, which is naturally produced and stabilised by our bodies.

Measures are also put in place by Profhilo to ensure that you are receiving an authentic Profhilo product and treatment. You can scan QR codes on authenticity stickers that can be found on all authentic Profhilo products to prevent health risks and complications.

Is Profhilo better than fillers and skin boosters?

Profhilo is an interesting product in which it is neither a dermal filler nor a skin booster. Not only does it have bio-remodelling properties stimulating collagen, elastin and adipocyte production it also adds volume to the face by providing deep skin hydration to smooth and even out the skin’s texture.

What also makes it effective is its high concentration of hyaluronic acid (HA), which is 5 times more than that of the average skin booster treatment at 64mg/2ml. This is also why it is commonly referred to as an “injectable moisturiser”.

How often do you need Profhilo?

It is advised that Profhilo be administered for at least two sessions, 4 weeks apart. A 3rd treatment may be done after 2 months, depending on skin laxity. Consequent treatments can be done 6-9 months apart for maintenance.

How quickly does Profhilo work?

As Profhilo is a bio-stimulator, results are best shown between 3-6 months. Over time, you will observe effects such as skin tightening, a reduction in fine lines and wrinkles, more luminous skin and a lifting effect.

Does Profhilo get rid of wrinkles?

Profhilo can help reduce fine lines and wrinkles as it uses pure hyaluronic acid and has bio-remodelling properties that help increase the firmness, volume and elasticity of the skin.

Can Profhilo be used under eyes?

Profhilo can be used under the eyes to reduce under-eye wrinkles and fine lines around the eyes. However, it is important to note that as Profhilo is not a dermal filler, issues related to volume loss, such as eye bags and dark eye circles cannot be addressed by this treatment.

Is Profhilo permanent?

The effects of Profhilo is not permanent. As our skin continues to age, we will need further sessions for maintenance and progressive improvement.

Does Profhilo lift jowls?

Profhilo is effective in treating loose skin in the jowls, as well as the neck and cheek, which are usually difficult to treat with other injectables. Across the board, it works well with tightening and firming loose facial skin, creating a lifting effect.

What should you not do after Profhilo?

After your Profhilo treatment, you should avoid:

  • Physically strenuous activities for 24 hours
  • Sauna or steamy baths for the first few days post-treatment
  • Alcohol at least 24 hours after treatment (or 7 days post-treatment for best results)
  • Facials, waxing, chemical peels, skin needling, microdermabrasion treatments
  • Makeup for at least 12 hours
  • Intense sun or UV exposure for the first few days

Can you have fillers and Profhilo on the same day?

You can have Neurotoxin treatment at the same time, but it is ideal to wait for at least two weeks before having other fillers in the same areas. Other treatments that utilise energy-based devices should also be held off as a precautionary measure.

How long do Profhilo lumps last?

Small lumps can form at the injection sites. These are perfectly normal and should subside within 4-6 hours of treatment. They can, however, last for up to a day.

Dr Shirley Kwee of Cambridge Medical

Dr Shirley Yuliana Kwee

Aesthetic Doctor and
Medical Director of Cambridge Medical Group
GDFM (Singapore)
Dr Shirley Kwee has amassed over 10 years of experience in Aesthetic Medicine and is a trusted practitioner by her patients. Her clinical interests and expertise include injectables (dermal fillers), threadlifts, treatments for skin pigmentation, anti-ageing, weight loss and body sculpting. She strongly believes in helping patients understand their individual beauty and to enhance them with personalised treatment plans and finding the right combination of treatments for her patients.
Dr Lee Mun Heng

Dr Lee Mun Heng

Aesthetic Doctor and Founder
of Cambridge Medical Group
With more than 15 years of medical aesthetics experience and a graduate of the world-renowned University of Cambridge in the United Kingdom, Dr Lee aims to draw out one’s natural beauty through the application of safe, minimally invasive and holistic procedures. He is also a key opinion leader in the realm of aesthetic technology, often travelling the world to seek out the latest and most effective treatments.

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We strive to help our patients look and feel their best.
Visit us for a detailed consultation and customised treatment plan tailored to your needs and concerns.
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